表面含Phosphorylcholine聚乙烯薄膜之製備及血液相容性之研究

• Main Author: 甄慧蓮
• Other Authors: 劉瑞祥
• Format: Others
• Language: zh-TW
• Published: 1997
• Online Access: http://ndltd.ncl.edu.tw/handle/86321579786643886923

碩士 === 國立成功大學 === 化學工程研究所 === 85 === To fabricate a biomimetic polymer, phosphorylcholine (PC) was introduced onto the surface of polyethylene (PE). Acrylic acid was graft-copolymerized on the surface of PE by UV-irradiation, including peroxide preirradiation method and simultaneous method. Benzophenone and Michler''s ketone were used as initiator and sensitizer in this investigation, respectively. PC was then introduced onto the surface of PE by a series of reactions. The modification of surface of PE were analyzed by contact-angle, FTIR-ATR, and ESCA techniques. The platelet-compatibility of the PC modified polymer was evaluated by in vitro platelet adherent test. It was found that PC structure on PE surface will improve the platelet-compatibility effectively, the length of lipophilic spacer between PC groups and PE surface will affect the biomimetic properties of polymer.