Mite(Der p 1,Der p 2), Cat(Fel d 1), Cockroach(Bla g 1) Allergens and Childhood Respiratory Illness

• Main Authors: Chen, Hsiu-Lin, 陳秀玲
• Other Authors: Su HJ, Lei HY
• Format: Others
• Language: zh-TW
• Published: 1997
• Online Access: http://ndltd.ncl.edu.tw/handle/87915798963520166897

碩士 === 國立成功大學 === 環境醫學研究所 === 85 === Exposure to indoor allergens has been shown to be associated with the occurrence of asthma. However, studies assessing multi-allergens simultaneously have not yet been adequate. This study examined a group of common indoor allergens at homes of asthmatic and healthy children in Taiwan to construct the pattern of their concentration distributions and for a comprehensive assessment of microbial exposure and their effects on respiratory outcomes of asthmatics.A representative group of asthmatic children (11-13 years old) from a typical metropolitan city of Taiwan was selected with a cross-sectional questionnaire survey. The healthy controls were matched by their age, gender, schools attending, and residence. Dust samples of the mattress were collected with standard vacuum (3 min/m2). After sieving and extract on, all samples were analyzed by different ELISA kits (Lymphocyte Culture Center, the University of Virginia) for various allergens. Health outcomes werMultivariate regression showed that the standard deviation of PFM values measured in the morning, afternoon, evening, and daily average of the 7 days and symptom scores of the subjects study were all positively associated with the Der p 2 concentration of the mattress. The degree of effect on respiratory health by exposure to Der p 2 allergens appeared to be stronger on the asthmatics than healthy children . The positive association between mite allergen concentrations and 7-day standard deviation of PFM vaThe study was the first investigation ever conducted in the subtropical region to evaluate the domestic concentrations of multi- allergens simultaneously with respiratory health outcomes of randomly-selected asthmatic and health children. The role of Der p 2 exposure affecting the respiratory symptoms of asthmatics appeared to be significant. In addition,the effect of allergens exposure on the outcomes of respiratory health seemed to be vary with the seasons. It was also found that the pattern of concentrati