| Summary: | 碩士 === 國立成功大學 === 環境醫學研究所 === 85 === Exposure to indoor allergens has been shown to be associated
with the occurrence of asthma. However, studies assessing
multi-allergens simultaneously have not yet been adequate. This
study examined a group of common indoor allergens at homes of
asthmatic and healthy children in Taiwan to construct the
pattern of their concentration distributions and for a
comprehensive assessment of microbial exposure and their effects
on respiratory outcomes of asthmatics.A representative group of
asthmatic children (11-13 years old) from a typical metropolitan
city of Taiwan was selected with a cross-sectional questionnaire
survey. The healthy controls were matched by their age, gender,
schools attending, and residence. Dust samples of the mattress
were collected with standard vacuum (3 min/m2). After sieving
and extract on, all samples were analyzed by different ELISA
kits (Lymphocyte Culture Center, the University of Virginia) for
various allergens. Health outcomes werMultivariate regression
showed that the standard deviation of PFM values measured in the
morning, afternoon, evening, and daily average of the 7 days and
symptom scores of the subjects study were all positively
associated with the Der p 2 concentration of the mattress. The
degree of effect on respiratory health by exposure to Der p 2
allergens appeared to be stronger on the asthmatics than healthy
children . The positive association between mite allergen
concentrations and 7-day standard deviation of PFM vaThe study
was the first investigation ever conducted in the subtropical
region to evaluate the domestic concentrations of multi-
allergens simultaneously with respiratory health outcomes of
randomly-selected asthmatic and health children. The role of Der
p 2 exposure affecting the respiratory symptoms of asthmatics
appeared to be significant. In addition,the effect of allergens
exposure on the outcomes of respiratory health seemed to be vary
with the seasons. It was also found that the pattern of
concentrati
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