| Summary: | 碩士 === 國立中興大學 === 獸醫學系 === 85 === Methotrexate (MTX) and bromocriptine (BrC) were used in this
study for terminating pregnancy in bitches. MTX can block DNA
synthesis. BrC can inhibit prolactin secreetion and decrease
serum pregesterone conxentration. Blood count, serum
biochemistry, and serum pregesterone concentrations were
analyzed in five normal pregnant bitches, five MTX (5 mg/M2)
treated bitches,and eight MTX (5 mg/M2) treated bitches in 5,
15, 25, 38 days of pregnancy.Strong side effects were found in
MTX treated bitches, especially in bitches with 25 or 38 day of
pregnancy. None of the eight pregnant bitches terminated their
pregnancy after MTX treatment. Four ultrasound confirmed
pregnant bitcheswere treated with BrC (0.1 mg/Kg). Serum
progesterone concentrations weredecreased immediately after the
first day of BrC treatment. Three bitches (40to 50 day of
pregnancy) were aborted within 2 or 3 days after BrC Treatment.
The fetus ultrasound image of a 30-day-pregnant bitch was
undertectable aftera 6 day BrC treatment. BrC is proved useful
in terminating mid or late pregnancy in bitches..
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