Characterization of Transmissible Venereal Tumor

• Main Authors: Yang, Shwu-ru, 楊淑如
• Other Authors: San-Duo Chen
• Format: Others
• Language: zh-TW
• Published: 1997
• Online Access: http://ndltd.ncl.edu.tw/handle/09776301734714691646

碩士 === 國立中興大學 === 獸醫學系 === 85 === Abstract From 1820, transmissible venereal tumor（TVT）was found in dogs world wide. The tumor appears on the external genitalia, and is transferred from dog to dog by coition. It occurs in oral or nasal cavity and many extragenital sites by licking, biting and scratching. Because the cytologic appearance of TVT cell is very similar to that of lymphoma, histiocytoma or mast cell tumor, it always makes confuse among them. Hence, it was tried to characterize TVT by histopathological appearance, immunocytochemical ains and ultrastructure. Histopathologically , TVT cells were compacted or grew in cords with delicate stroma. Ultrastructurally, they had large, round nuclei and large central nucleoli, that contained bulk of euchromatin. The nucleus/cytoplasm ratio was about 1:1, and the cytoplasm was abundant with many free ribosomes, rough endoplasmic reticulum（ rER）, mitochondria, Golgi apparatus, and some lysosomes. The cytoplasmic membrane formed numerous microvilli interdigiting between adjacent cells. In some case when tumor cells degenerated, the cisternae of the rER was dilated and mitochondria showed variable degrees of swelling. In the immunocytochemical stains of TVT, vimentin immunoreactivity was detected in 7/9 TVT, all TVT cells were negative to desmin, S-100, neurone-specific enolase（NSE）, and cytokeratin. These findings proposed that TVT is mesenchymal in origin. 91