Studies on Slugging and Recompression Characterisation of some Blends of three Common Pharmaceutical Excipients

• Main Author: 林任士
• Other Authors: 詹道明
• Format: Others
• Language: zh-TW
• Published: 1997
• Online Access: http://ndltd.ncl.edu.tw/handle/07545917256284660075

碩士 === 高雄醫學大學 === 藥學研究所 === 85 === Slugs of Avicel PH102, Lactose fast-flo 316 and Di-tab were compressed, either on their own or in soddium chloride, captopril combinations, between 10.0mm flat faced punches on a hydraulic press at 7 different pressures. 100 tablets of each batch were compressed and the crushing strengths, the friabilities, the tensile strengths and the densities were determined. In addition, the dissolution rate of captopril was also determined. The 50 remaining slugs were screened through an hammer granulator and recompressed at the same pressure used initially. The characterisations of the final tablets were again determined. The mean yield pressures were evaluated for the slugs utilizing Heckel analysis. The results indicated that the highest tensile strength were produced using 100% Avicel PH102. The mean yield pressure values showed that on addition of sodium chloride to Avicel PH102 there is a move away from predominantly plastic deformation and to Di-tab there is a move away from deforming by fragmentation. It would seem that fragmentation of Di-tab enhances bonding on compaction and so leads to increased crushing strength after re-compressed. However, except 25% Avicel PH102 75% sodium chloride blends, for all slugged tablets containing Avicel PH102 there was a reduction in the crushing strength of the tablet after the second compression. This would indicate that the extent of plastic deformation is less when the materials are compressed twice, compared to when the materials are compacted once. It was concluded that the slugging process is therefore independent of an increase in dwell time.