| Summary: | 碩士 === 高雄醫學院 === 藥學研究所 === 85 === (S)-4-isopropyl-N-(3-tributylstannylpropionyl)oxazolidinone
20 是一個對掌鈦對映烯醇基的前趨物,它可以和醛類反應,如 p-
nitrobenzaldehyde,而進一步得到相對應的醇類. 在論文第二部分,我們
完成對掌鈦複合體催化β-stannane methyl propnoate 25 和醛類的加成
反應.在本論文中,我們利用對掌雙醇34 和35來生成對掌鈦複合體,這個反
應直接得到相對應的γ-對掌丁內酯,沒有分離中間產物γ-hydroxy
esters,然而,所有最終得到的γ-丁內酯均為消旋體.
(S)-4-isopropyl-N-(3-tributylstannylpropionyl)oxazolidinone
20 was used asa precursor of chiral titanium homoenolate, which
reacted with an aldehyde,such as p-nitrobenzaldehyde, to give
the corresponding alcohol. In the secondpart of this thesis, we
completed the investigation of chiral titanium complexes
catalyzed addition reactions ofβ-stannane methyl propanoate 25
with aldehydes. Chiral diol ligands 34 and 35 were used in this
study to generate chiral titanium complexes. These reactions
led directly to the corresponding γ-butyrolactones without
isolation of intermediateγ-hydroxy ester.However, all the final
the finalγ-butyrolactones were examed as racemic mixture.
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