The effect of transdermal estradiol on hormone and metabolic dynamics in menopausal women

• Main Authors: Wu, Chin-Ming, 吳錦明
• Other Authors: Su Jinu-Huang
• Format: Others
• Language: zh-TW
• Published: 1997
• Online Access: http://ndltd.ncl.edu.tw/handle/59343957060133663444

碩士 === 高雄醫學院 === 醫學研究所 === 85 === Although various regimens of hormonal replacement therapy (HRT) have beenestablished, HRT can certainly be improved in several ways. A transdermaldelivery system of estradiol was applied to two groups of menopausal women.Group A included 22 menopausal women followed at gynecological OPD. The transdermal patch, Estraderm TTS 50, which contains 4 mg Estradiol-17B withdrug delivering rate of 50 ug of E2 per day, was applied to the arms legsand lower abdomen twice a week. Serum hormone levels (such as FSH,LH,E2),liver function test, renal function test and cholesterol levels were measured before skin patches usedand 1, 2, 3 months after application, respectively. Seventeen of 22 womencompleted the treatment course and the other 5 women could not tolerate theskin irritation. Significant increase in estradiol serum levels as well as asignificant decline in FSH, LH, serum levels were noted. However, there wasno significant change in other parameters. Group B included 5 menopausal women,used patches 14 days after bilateral oophorectomy. Short term changes of FSH,LH, E2 were evaluated. Significant changes were noted only at 24 hours after application. It seems that the rate of drug uptake by the skin of menopausalwomen in south Taiwan is not quite optimal, or that the subtropical climateof Kaohsiung influences the skin characters, such as hydration. Further surveysare needed to evaluate the detailed changes. Despite of its side effect of skin irritation, the transdermal delivery system of estradiol is still a goodregimen of HRT.