Analysis of the Sequences Responsive to TGF-β of Prolactin Promoter
碩士 === 國立陽明大學 === 生物化學研究所 === 84 === TGF-β可以抑制泌乳激素 (prolactin)mRNA之表現。本論文以GH3腦下垂體腫瘤細胞株為模型,尋找泌乳激素基因啟動子(promoter) 與 TGF-β抑制作用有關的 DNA序列。以不同區域的泌乳激素基因啟動子驅動 Luciferase gene 表現,發現 TGF-β可透過全長 2.5kb或近端 0.6kb與遠端 1.9kb啟動子抑制luciferase的表現。我們對近端啟動子作刪除 (deletion)分析發現 TGF-β無法透過只含泌乳激素基因的TATA box來抑...
Main Authors: | Tai, Lung-Kuo, 戴榮國 |
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Other Authors: | Cheng, Fung-Fang |
Format: | Others |
Language: | zh-TW |
Published: |
1996
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Online Access: | http://ndltd.ncl.edu.tw/handle/93852758364677329137 |
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