| Summary: | 博士 === 台北醫學院 === 藥學類 === 84 === Alkannin/shikonin (A/S) is a major component in crude drug
"Shikon", which is used as a major ingredient to prepare
Shiunko ointment for the treatment of wounds, skin disease, and
burns. Photochemical decomposition of A/S under sunlight mainly
leads to (-)-5,8-dihydroxy-2-(1-hydroxy-3-oxo-4-methyl-4-
pentenyl)-1,4-naphthoquinone, a newly discovered naphthoquinone
analogue, through the photo-oxidation process. The
photodegradation of A/S follows an apparent first-order
kinetics. A/S was subject to degradation by light source,
solvent polarity, oxygen content in the solution, container
material, and pH but not affected by ionic strength. The results
of kinetic studies imply that a free radical reaction was very
likely involved in the photolytic process of A/S. The
solubility, photostability, and in-vitro permeability of A/S
could be significantly improved through the formation of
inclusion complex of A/S with HPCD. The existence of A/S-HPCD
inclusion complex was elucidated through FTIR, DSC, and powder
X-ray diffractometry.
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