| Summary: | 碩士 === 國立臺灣大學 === 獸醫學系 === 84 === The efficacies of low-dose heparin and low-dose heparin with
ticlopidine as anticoagulants during hemodialysis in dogs were
compared and evaluted. Five healthy dogs of body weight ranging
23-33 kg were hemodialyzed with heparin as the sole anti-
coagulant which was administered at a dose of 40 IU/kg (initial
dose) and 30 IU/kg/day (maintenance dose). Groups II and III
were hemodialyzed with heparin at the same dose and together
with two regimens of ticlopidine, 50 mg/kg/day and 100 mg/kg/
day respec- tively. Ticlopidine was administered orally once a
day at the doses mentioned above 72 hours prior to
hemodialysis, and the evaluation of ALT, BUN, creatinine, blood
cell count, APTT and fibrinogen levels was carried out before
each administration. The period of each hemodialysis was 3
hours. Parameters monitored during hemodialysis included APTT,
fibrinogen levels, blood cell count, BUN, creatinine and
residual blood weight. Systolic arterial pressure, diastolic
pressure, pulses and mean arotic pressure were also recorded
via automatic sphygnooscillometer at five minutes intervals
before, during and after hemodialysis. No significant
differences of those evaluated parameters mentioned above were
found among dogs which were pretreated with ticlopi- dine. A
significantly lower degree of hemodialysis-associated
leukocytopenia was found in both groups II and III than that of
group I. However, no significant differences were observed
between the groups II and III. In addition, dose-dependent
reduction of residual blood weight was observed in the groups
II and III. A much less degree of hemodialysis-associated
thrombocy- topenia was observed in group III as compared to
group I. According to the salutary effects demonstrated above,
the combi- nation of heparin and higher ticlopidine regimen may
be more clinically benefic.
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