| Summary: | 碩士 === 國立臺灣大學 === 醫事技術學系 === 84 === Respiratory syncytial virus (RSV), a single stranded RNA virus,
is the most important respiratory pathogen of infancy and early
children. Its presence may be witnessed in most communities in
many places by the yearly upsurge of pneumonia, bronchilitis,
and tracheobronchitis in the very young children. In order to
understand the epidemiological distribution of RSV in Taipei,
135 isolates from National Taiwan University Hospital during
1984-96 were investigated using reverse transcription-
polymerase chain reaction(RT-PCR) followed by restriction
enzyme mapping. Restriction fragment analysis toward the
amplified G gene revealed 10 genotypes for subgroup A ,and Ga1
comes to be the predominant genotype(66.3%). Other genotypes of
subgroup A were: Ga2 8%, Ga3 5%, Ga4 5%, Ga5 4%, Ga6 3%, Ga7
3%, Ga8 1%, Ga9 1%, Ga10 3%. The subgroup B virus reveal only 3
genotypes, and the predominant genotype was Gb1(86.5%).The
distribution of Gb2, Gb3 were 8% and 5%. Subgroup A showed
higher infection rate for male and children under 6 months. In
the clinical manifestation, sub- group A patients show higher
intensive care needs and longer period to recover from RSV
infection while the clinical diagnosis seems to have no
distinct differences. This study not only improve our
understanding toward the RSV G protein genotypes distribution
in Taipei, but also provides a feasible way to identify
nosocomial RSV infection.
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