A Study of Catalyzed Reaction of Synthesizing of 2-Mercapbenzimidazole and Its Derivatives

• Main Authors: Liu, Biing-Lang, 劉炳郎
• Other Authors: Wang Maw-Ling
• Format: Others
• Language: zh-TW
• Published: 1995
• Online Access: http://ndltd.ncl.edu.tw/handle/28104215466044910268

博士 === 國立清華大學 === 化學工程研究所 === 84 === In this dissertation, 2-mercaptobenzimidazole (MBI), which was synthesized from the catalyzed reaction of o-phenylenediamine and carbon disulfi- de by tertiary amine or quaternary ammonium salt either in a homogeneous solution or in a two-phase medium, was studied. The MBI derivatives were syn- thesized by reactant catalyzed by quaternary ammo- nium salt in an alkaline solution of KOH/organic solvent two-phase medium. The products MBI and its derivatives, which are important intermediates of specialty chemicals, are used as inhibitor, anti- oxidant, antiseptic, and adsorbent in industries, and durg for medicine care. The reactions were greatly enhanced by adding a small catalytic amo- unt of tertiary amine or quaternary ammonium salt and/or in the presence of potassium hydroxide. The yields of products MBI and its derivatives are in- creased by employing the present methods in this study. Several rigid results were obtained from the synthesis of 2-mercaptobenzimidazole(MBI) in a ho- mogeneous solution and in a liquid-liquid two-pha se medium, and the derivatives of MBI by phase transfer catalysis was also investigated experi- mentally in detail. Rational kinetic models were built up based on the effects of the operating conditions on the reaction rates. A pseudo-first order rate law model, was simplified from the o- riginal kinetic model, was sufficient to describe the behavior of reaction in a homogeneous solut- ion, in a liquid-liquid two- phase solution and in a gas-liquid reaction solution.