| Summary: | 碩士 === 國立中央大學 === 化學工程學系 === 84 === Clinically, there is a great demand on small-diameter vascular
grafts, including the grafts for
coronary artery bypass and peripheral vascular
vessel replacement, the A-V shunts for dialysis, and the B-T
shunts for congenital heart
repair,etc. Although the biostability of autografts and
homografts is satisfactory in their clinical use, the resource
of these grafts is limited. On
the contrary, there is no limitation in heterograft
resource. However, previous clinical results have shown that
the cross-linking characteristics of the
glutaraldehyde-fixed heterograft is poor. The problems
encountered with the glutaraldehyde-fixed heterograft
are thrombosis, calcification, and poor
plibility. It is thought that these problems may be related
with the chemical reagent,
glutaraldehyde, used in fixing heterograft. To overcome
these problems, we plan to use a new fixation reagent, epoxy
compound, to treat heterograft. Also
since the annual pig production in Taiwan is about 13
millions, we decided to use porcine artery as our heterograft
raw materials. The study is to
investigate the biostability of the epoxy compound-fixed
heterograft. The results of the study will allow us to evaluate
if the epoxy compound-fixed heterograft
is feasible to use as a small-diameter vascular
graft in clinical practice.
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