Quantitative Analysis of Saccadic Eye Movements

• Main Authors: Chun-Hsien Lin, 林俊賢
• Other Authors: Tain-Somg Chen, Jia-Jin Chen
• Format: Others
• Language: zh-TW
• Published: 1996
• Online Access: http://ndltd.ncl.edu.tw/handle/66840749181072685788

碩士 === 國立成功大學 === 醫學工程學系 === 84 === Recent studies have indicated that the latency ,peak velocity, and accuracy of saccadic eye movements of patients with Parkinson's disease(PD) are different from those of age matched control subject. Thus, these quantitative measurements of eye movements could be used for assessing the severity of Parkinsonism. The horizontal saccadic eye movements detected by surface electrodes are sampled by an A/D converter with 12-bit resolution at a 500 Hz sampling rate. For automatic data analysis, the Kalman filtering approach is used for the detection of the initial point of saccadic nystagmus. In addition, the system parameters of second order system, such as damping ratio and natural frequency, are used for the description of eye movements charact eristics. Eight patients with mild Parkinsonism (stage I) and eight patients with advance Parkinsonism (stages II and III) are recruited for saccadic eye movement study.Besides , ten normal young adults and nine elderly subjects form the reference group. Our results show that longer latency, lower peak velocity, and less accurate response in the saccadic eye movement can be observed at elderly normal and subjects with advanced Parkinsonism. These findings from the conventional eye movement measurements are consistent with the published data. In addition, we have also found that the system parameters developed in this research are more sensitive than those of conventional measurements in differentiation of the severity of Parkinsonism. These conclude that the system parameters might be a better index for the assessment of eye movement for subjects with Parkinsonism.