The gastrointestinal adverse effects and prescribing patterns of nonsteroidal anti-inflammatory drugs

• Main Authors: Chan, Yu-Min, 陳昱旻
• Other Authors: Kin-Wei Arnold. Chan, Yea-Huei K. Yang
• Format: Others
• Language: zh-TW
• Published: 1996
• Online Access: http://ndltd.ncl.edu.tw/handle/65266492031450233638

碩士 === 國立成功大學 === 臨床藥學研究所 === 84 === Nonsteroidal anti-inflammatory drugs (NSAIDs) have been found to be associated with an elevated risk of peptic ulcer and upper gastrointestinal hemorrhage. A retrospective cohort study was performed to estimate the incidence and cumulative incidence of serious ulcer disease among long-term users of NSAIDs, using a computerized prescriprion data base of National Cheng-Kung University Hospital. Twenty-eight thousand seven hundred and seventy four NSAID recipients, who had NSAID prescription record, were included. Three hundred and ten patients became the study cases after medical record review and two hundred and forty-two were interviewed via telephone. Incidence of serious ulcer disease was between 11.7 per 1,000 person-year (95% confidence interval 1.4-22.0) and 15.6 per 1,000 person-year (95% confidence interval 1.9-29.3). Cumulative incidence of serious ulcer disease was between 1.61% (95% confidence interval 0.53-3.72) and 2.07% (95% confidence interval 0.67-4.76). The second objective in this study was to describe the prescribing patterns of NSAIDs users. Osteoarthritis was the most commonly listed indication. Among these NSAIDs, diclofenac SR was prescribed most often in terms of defined daily dose. The department of Orthopaedics prescribed the most of NSAIDs. Within the limits of statistical error, the results of this study was similar to that presented in previous reports. These drugs should be used with caution, and alternatives to NSAIDs should be strongly considered.