| Summary: | 碩士 === 中山醫學院 === 營養科學研究所 === 84 === There was abundant Arecaidine and rare guvacolinein aqueous
extract of betel quid. The measurements ofpolyphenolic showed
that the aqueous extract of betelquid contained rich condensed
tannins and scarce sim-ple phenolics. The contents of alkaloids
and polyphe-nolics in the aqueous extract of betel quid did not
change after low etmperature storage nad freeze dryi-ng process.
Salmonella microsomal studies showed that aqueous extract of
betel quid, nicotine and mixtureof nicotine and aqueous extract
of betel quid did not induced the mutagenicities in Salmonella
typhimuriumTA98 and TA100 with nad without S9. Eukaryotic cell
（CHO cell）studies showed that all three samples didnot evoke
chromosomal aberration, but they increased the frequencies of
sister chromatid exchange in a co-ncentration dependent manner.
Animal （Sprague-Dawleymale rat）studies urvraled that low dose
of aqueous extract of betel quid feeding significantly increased
the activities of GSH peroxidase and cGST of liver, high dose of
aqueous sxtract of betel quid feeding lowered the contents of
reduced CSH and total GSH, middle dose of aqueous extract of
betel quid feedingwith nicotine treatment （hypodermic injection
）redu-ced the TBARs values raised the GSH peroxidase activ-ity.
It qppeared that both betel quid and nicotine could activate the
self-protection of animal. Study on the formation of free
radicals showed that all th-ree samples promoted the formation
of free radicals via the measurement of 8-（OH）-dG generation.
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