| Summary: | 碩士 === 台北醫學大學 === 生藥學研究所 === 83 === The development of immuninal drugs, in clinical, for example Lentinan, PSK...etc. they all belong to natural polysaccharides. In traditional Chinese medicines which classified by their odors : acid, bitter, sour, salty, sweet. Among these five types, the function of sweet type, is the similar as immunomodulator. The experiment selected eighteen Chinese herbs which are all belong to sweet type. Extracted crude polysaccharides, and orally to CDF1 mice which is induced P388 tumor cells. The result of anticancer activity is increasing from control T/C% =100% to Atractylodes macrocephala T/C%= 130%. Therefore, we hope to look for the active polysaccharide of A. macrocephala, Using chromatography of DE52 and Sephadex G-75, achieve three compounds : AM-a, AM-b, AM-c. Their molecular weight 7000, 10500, 12000. Specific rotation:-40.2, -57.04, +43.65. Its constitution of respectiviy. AM-a : 92.3% is mannose. AM-b is 38.7% fructose, 35.5% glucose and AM-c is 73.4% mannose.
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