Studies on the Tannins and Related Compounds from Quisqualis indica Linn. and Acalypha indica Linn.

• Main Author: 莊峻毅
• Other Authors: 徐鳳麟
• Format: Others
• Language: zh-TW
• Published: 1995
• Online Access: http://ndltd.ncl.edu.tw/handle/13916268523894618208

碩士 === 台北醫學大學 === 藥學研究所 === 83 === Recent development in tannin chemistry and the discovery of new biological activities have drawn attentions in the investigation of tannins as medical agents. Therefore, a chemical investigation of tannins and related compounds in the fruit of Quisqualis indica and the dried herb of Acalypha indica was undertaken. 　Quisqualis indica Linn. (Combretaceae), which is originated from tropic India and southest Asia, and its fruit used as folk medicine for anthelmintic and digestive disorders. By means of various column chromatography, seven compounds (1~7) were isolated and purified. The structure of these compounds were elucidated as protocatechuic aldehyde (1), protocatecuic acid (2), gallic acid (3), brecifolin carboxylic acid (4), 1-O-galloyl-β-D-glucose (5), 2, 3-hexahydroxydiphenoyl-D-glucose (6) and castalagin (7). Among them, castalagin (7) was the major component. 　Acalypha indica Linn. (Euphorbiaceae) is a common tropic plant distributed over Asia and Africa. According to the literatures, it contains antibiotic agents and the emetic alkaloids. From the dried herb, twelve compounds (5 and 8~18) were obtained and their structures were elucidated as quercetin -3-O-glucoside (8), rutin (9), 1-O-galloyl-β-D-glucose (5), 1,2,3,6-tetra-O-galloyl-β-D-glucose (10), corilagin (11), geraniin (12), acetonylgeraniin A (13), euphormisin M2 (14), repandusinic acid A (15), chebulagic acid (16), potassium brecifolin carboxylate (17) and acaindinin (18). Among them, corilagin and geraniin were the major components. Potassium brevifolin carboxylate (17) and acaindinin (18) were isolated for the first time from the plant source.