| Summary: | 碩士 === 國立臺灣大學 === 免疫學研究所 === 83 === The prevalence of allergic diseases have increased in recent
years.Both in vivo and in vitro evidences suggested Th2 cells and IL-4,IL-5 are important in pathogenesis of allergic diseases.The rational of immunotherapy is to downregulate predominant Th2 responses and increase Th1 activity in atopic patients.In order to know further what kinds of immunological changes make immuno- therapy effective,we followed a serial study on asthmatic child-ren who are allergy to HDM.We isolated PBL before,during 4 and 8 months after IT.Our results showed:(1)The productions of anti- HDM antibodies IgG4(P<0.01) and IgG1 increase 8 months after IT but IgE remains no changes .(2)The secretion ability of Th2 cytokines by PBL decreases after IT.(3)Chemokines which induce histamine production by basophil and monocytes decrease .(4)IL-13, which can induce IgG4,IgE antibody productions by B cells increases instead of decrease after IT.Most studies showed increased IgG1 and IgG4 allergen-specific antibosies during IT.
This finding is actually against the hypothesis of T helper
cells switch.In our study, we found although the Th2 cytokines
decreased, the IgG4 and IgG1 productions increased instead of
decreased.Our study indicated production of IL-13 that can
induce productions of IgG4 and IgE increased instead of
decreased after 8 months of IT.It is possible that IL-13 is
important in inducing IgG4 and IgG1 productions during IT. It
could be a future study goal to elucidate the mechanism of how
does IL-13 interact with other cytokines and how do these
interactions interfere asthma pathogenesis in order to further
elucidate the IT mechanism.
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