| Summary: | 碩士 === 國立成功大學 === 化學工程研究所 === 83 === Resolution of racemic (±) 1-phenethyl alcohol via PPL(porcine
pancreatic lipase) in organic solvents by transesterification
with vinyl acetatet was carried out in this investigtion。
Solvent effect on the stereospecificity of the enzyme was
investigated。It was found that the reaction rate have a good
correlation with hydrophobicity constant log P，and the
reaction rate increased with increasing the polarity of solvents
。 PPL at higher temperature stil have good thermal catalysis，
this shows that the PPL has a better stability in organ ic
solvent than in water。 PPL in water saturated n-heptane have
higher reaction rate and lower enantioselectivity than in
dehydrated n-heptane。In triethyl amine,howeve,added of water
caused the decreasing of PPL activity and the
enantioselectivity almost not be affected。 In the presence of
chiral polymer TDI-CPO,the reaction system in tetrahydrofurane
was found that the reaction rate and the enantiomeric ratio of
the system were both increrased。
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