Preparation and Biological Evaluation of Poly D,L lactide/ Tricalcium phosphate Powder Composite as Bone Substitute

• Main Authors: Wang ,Jin Wen, 王建文
• Other Authors: Chang, Yen Lin；Lin, Feng Huei
• Format: Others
• Language: zh-TW
• Published: 1995
• Online Access: http://ndltd.ncl.edu.tw/handle/65208400414287161435

碩士 === 中原大學 === 醫學工程學系 === 83 === Polyesters based on lactic acid have been reported safty and biodegradation in the human beings for two decades. The greatest advantage of the material is its degradatio only conducted by the hydrolysis, where the ester backbones are supposed to be unchained in the aqueous condition. The final degradable product are carbon dioxide and water that can be metabolized and digest- ed in the physiological environment. The goal of this study was aim to develope a composite combined with poly-DL-lactide(PDLLA) and tricalcium phosphate(TCP) ceramic particles as orthopaedic application. The TCP particles in a range of 0-60wt%(with 5wt% increment) were doped into the PDLLA matrix for the reinforcement, which were prepared by the melting and hot pressing technique. The basic mechanical strength, biodegradable behavior, and bio- logical response of the composites will be investigated in the study. Various techniques, such as pH meter, UV, FTIR, XRD etc., were used to examine and record the degradable process of the composites soaked in the Ringer''s solution for 1-12 weeks. The cell culture, rats subcutaneous implant and rabbit femur con- dyle fracture fixation test were used to evaluatethe cytotocity , tissue compatability, and effects of bone fracture fixation of the composites, respectively, The histological observation and x-ray photography were applied for investigating assistance. The mechanical strength of the composites initially with TCP additions upto 50wt%, thgereafter, showed no significant differ- ence(p>0.05). The composite with 50wt% TCP addition showed high mechanical strength and had a great agreement with cortical bone in elastic modulus of 37MPa. The weight loss of the pure PDLLA soaked in the Ringer''s solution was started at 4 weeks and reac- hed to 80wt% after 12 weeks. The composites compared with pure PDLLA, however, showed no apparent evidence for degradation after soaked for 12 weeks.