Phytochemical Studies on the Fruits of Formosan Evodia Genus Plants

• Main Authors: Lie Chwen Lin, 林麗純
• Other Authors: Kuo Tung Chen
• Format: Others
• Language: zh-TW
• Published: 1994
• Online Access: http://ndltd.ncl.edu.tw/handle/98516051049430233058

博士 === 台北醫學院 === 藥學研究所 === 82 === @ Wu-Chu-Yu, the dried unripen fruit of Evodia rutaecarpa (i.e. Fructus Evodiae ), is a commonly used Chinese medicine and well documented in Chinese medical book " Sheng Nung Pents''ao Ching ". Traditionally, Wu-Chu-Yu has been used for the treatment of headache, abdominal pains, dysentery, post- partum hemorrhage and amenorrhea. Wu-Chu-Yu contains a variety of quinazolinocarboline alkaloids including evodiamine, rutaecarpine, and dehydroevo- diamine. These compounds were found to be active in cardio- tonic( evodiamine ), uterotonic( rutaecarpine and dehydro- evodiamine ), vasodilative( dehydroevodiamine ), hypotensive( dehydroevodiamine ),and antiarrhythmic ( dehydroevodiamine ) actions. Since there are Evodia rutaecarpa, E. merrillii, E. meliaefolia; and E. lepta that belong to Evodia genus in Taiwan, study of the constituents of these Evodia fruits, therefore, became our interest. The alcoholic extracts of the dried unripen fruits of Evodia genus were charged to column chromatographic metho- dology for separation and purification of its constituents. From E. Fructus, a new quinazolinocarboline alkaloids( 7- hydroxyrutaecarpine ) was obtained; from E. merrillii, six novel acetophenones [ 4-(1''- geranyloxy)- 2,6-di-hydroxy-3- isopentenylacetophenone, 2 - (1''-geranyloxy)- 4,6-dihydroxy acetophenone, 4 -(1''-geranyloxy)-2, 6-dihydroxyacetophenone, 4-(1''-geranyloxy)- 2,6,β-trihydroxyacetophenone, 4-(1''- geranyloxy)-2,6,β -trihydroxy-3-dimethylallylacetophenone, and 2-(1''-geranyloxy)-4,6,β-trihydroxyacetophenone] were isolated; from E. meliaefolia, 17 known compounds were isolated; and from E. lepta , a novel acetophenone C-glyco- side ( 2,4,6-trihydroxyacetophenone-3,5-di-C-glucoside) was isolated. Overall, thirty eight compounds were isolated and iden- tified from the fruits of Evodia plants in Taiwan, and eight of them were characterized as new compounds.