Synthesis,Characterization and Hydrolysis of Poly(L-lactide) Copolymers

• Main Authors: Jiuun-Chi Chen, 陳駿奇
• Other Authors: David Shiaw-Guang Hu
• Format: Others
• Language: zh-TW
• Published: 1994
• Online Access: http://ndltd.ncl.edu.tw/handle/08915252329667828727

碩士 === 國立臺灣科技大學 === 纖維工程技術系 === 82 === Two new types of boidegradable polymer materials, copoly(L- lactic acid/succinic anhydride/ethylene gl- ycol) and copoly(L- lactic acid/succinic anhydride/po- lyethylene glycol),was synthesized by means of direct copolycondensation of EG or PEG( molar mass=200) with diacid, synthesized from L-lactic acid and succinic anhydride,in the presence of a Ti(OBu) or SnOc cata- lyst. The copolymers were characterized by GPC , IR , H- NMR and contact angle.The first-order kinetics is used to caculate the rate constants of hydrolysis reaction.The results indicate that the lower reaction pressure,the higher molecular weight of copolymers.T- here is no discernible difference between the Ti(OBu) and SnOc catalysts in polymerization,as far as mole- cular weight of products and yield of reaction is concerned. The rate constant for more hydrophilic copoly( LA/SA/PEG) is higher than copoly(LA/SA/EG).Ta- king into account the rate constants of PLLA,PEG/PLLA triblock copolymers in the previous study and copoly- mers in this study that the rate constants of hydrol- ysis for lactic acid biodegradble polymers is correl- ated with the ratio of no. of ester to no. of carbon on main chain.