| Summary: | 博士 === 國立臺灣大學 === 獸醫學研究所 === 82 === The studies were aimed to investigate the incidence and the etio-logy of bacterial penumonia in large intensive hog operations, to evaluate the therapeutic effects of various antimicrobials against major bacterial respiratory diseases in swine and poultry, and to conduct kinetic studies on tissue levels or residues after the administration or withdrawal of the antimicrobials in swine and poultry. The bacterial respiratory diseases involved in these studies were Actinobacillus pleuropneumonia(AP),Pasteurella pneumonia(PP),Mycoplasma pneumonia(MP) of swine and the chronic respiratory disease of poultry. Eight antibricrbials including lincomycin, lincomycin-pectinomycin,
neomycin,tylosin,tiamulin, ceftiofur, enrofloxacin and
sulfamethazine were investigated.
The results revealed that 49.8% of pigs examined had pneumonic lesions, including 37.9% of MP, 8.9% of MP in combination with bronchopneumonia, and 8.7% of AP.
The studies showed the effective dose regimes of lincomycin- spectinomycin and ceftiofur for treatment of AP, ceftiofur and enrofloxacin for treatment of PP, lincomycin and lincomycin-sulfamethazine for the improvement of weight gain and feed efficiency on pigs with clinical or subclinical MP, and lincomycin-spectinomycin against CRD.It also showed that tiamulin is not effective for treatment of AP and tylosin is not effective for treatment of PP.
The tissue levels of lincomycin were shown after the
administration of lincomycin-spectinomycin via drinking water in chicks, and the residues of lincomycin, neomycin and sulfamethazine were also shown after the administration and withdrawal of lincomycin, lincomycin-neomycin and lincomycin-sulfamethazine by feed medication in swine.
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