Inhibition by methylmercury chloride of nitrite generation induced by lipopolysaccharide in the rat primary cerebral cortical-glial cultures.
碩士 === 國立臺灣大學 === 毒理學研究所 === 82 === LPS 可誘發 NOS 的產生及其活性之增加隨 LPS 濃度成正比關係。MMC抑 制 LPS induced NOS 活性隨濃度增加而增加(10-9到10-6M),結果顯 示 MMC抑制 NOS 表現是影響 NOS protein 生合成以前的步驟,對 NOS 本身的活性沒有抑制作用。為進一步探求甲基汞作用機轉,我們試驗 H89 (是一種 specific PKA 抑制劑 )...
Main Authors: | Chia-Lung Hsu, 徐嘉隆 |
---|---|
Other Authors: | Shoei-Yn Lin-Shiau |
Format: | Others |
Language: | zh-TW |
Published: |
1994
|
Online Access: | http://ndltd.ncl.edu.tw/handle/30166084641605990625 |
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