The Pharmacological Studies of Anti-inflammation and Analgesia of Balanophora spicata

• Main Authors: Chein Ching, 經綪
• Other Authors: Huei-Yann Tsai
• Format: Others
• Language: zh-TW
• Published: 1994
• Online Access: http://ndltd.ncl.edu.tw/handle/55277919496164141479

碩士 === 中國醫藥學院 === 中國藥學系 === 82 === Balanophora spicata Hayata (B.S.) is a parastic plant of Balano- phoraceae. It grows on the roots of host plants, and is distributed in the broad-leaved forests throughout Taiwan. The flowering period is from October to January. It has been used as a folk medicine in Taiwan to increase strength, sobering up from drunkness, reducing fever and as an antidote. Since there was few reports about its pharmacological effects, we separated it into spikes (BSS) and rhizoma (BSR) to study the antiinflammation and an algesic effects. The following are results from our study. 1. The crude extracts of BSS (spike) and BSR ( rhizoma) inhibited the early and late phase of pain response induced by 1 ﹪ formalin. The BS is more effective on the late phase than the early phase. And we obtained the similar effects in different extracted layers were obtained. 2. The crude extracts of BSS and BSR also inhibited the acetic acid - induced writhing response in mice. 3. The components of hexane layer of BSR were Germacrene B, β - amyrin palmitate, lupeol palmitate, lupeol stearate, lupeol acetate and β - amyrin. Among them, lupeol acetate was the most abundant. Lupeol acetate inhibited the late phase of pain response induced by 1 ﹪ formalin at 10 mg/kg. It also inhibited the acetic acid -induced writhing response in mice. 4. In antiinflammatory effects, BSS, BSR, different layers and lupeol acetate all inhibited the early and late phases of edema induced by 1 ﹪λ -carrageenin. 5. In skin window test, BSS and BSR inhibited the increase in vascular permeability. From above results, it was suggested that BS have anti- inflammatory and analgesic effects. Its mechanism might be related to the inhibition of inflammatory substances in peripheral and in central nervous system. The pharmacological effects of its active components ( e.g. lupeol acetate) need to be further investigated.