| Summary: | 碩士 === 中國醫藥學院 === 中國藥學系 === 82 === Palmatine, an active constituent isolated from Chinese herbs，
such as Fibraura recisa, Cordalis yanhusuo,Coptis chinensis,
Phellodendron amurense et al, possesses anti-bacterial,
sedative and antiarrhytymic effects. In this study, the
pharmacokinetic and bioavailability of palmatine in rabbit were
evaluated. A selective and sensitive reversed-phase high-
performance liquid chromatographic method were developed for
the determination of the palmatine concentration in plasma. The
separation method is effective and precise. It could be applied
in the determination of the palmatine concentration in plasma .
The bioavailability of the palmatine were studied in 6 rabbits
by a three-way cross-over design. The venous blood samples were
collected at several fixed time intervals after the drug
administration, for I.V. (10 mg/kg), I.M. (10 mg/kg) and P.O.
(90 mg/kg), respectively. All plasma samples were assayed by
HPLC method and data were treated by computer programs: LAGRAN-
P and PCNONLIN.When the palmatine give to the rabbit by
intravenously, it exhibits two compartment pharmacokinetics,
but if give orally, it exhibits one compartment
pharmacokinetics. The pharmacokinetic behaviors following these
three different route of drug administration are quit
different. The bioavailability of I.M. rout was approximate to
100%. However, the bioavailability of P.O. was extremely low,
only 1.7%.
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