Development of matrix materials for direct compression of ontrolled release dosage forms
碩士 === 台北醫學院 === 藥學研究所 === 81 === The results indicated that the physical properties of the tablets are good. Larger amount of Surelease ( The aqueous dispersion of 25% ethylcellulose ) used in the formulation ( 1% to 10% ) would result...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
1993
|
| Online Access: | http://ndltd.ncl.edu.tw/handle/84857448661289204786 |
| Summary: | 碩士 === 台北醫學院 === 藥學研究所 === 81 === The results indicated that the physical properties of the
tablets are good. Larger amount of Surelease ( The aqueous
dispersion of 25% ethylcellulose ) used in the formulation ( 1%
to 10% ) would result in slower drug dissolution. There
shows no significant difference of characteristics between
lactose and dicalcium phosphate. Compared to commerical pro-
duct, the controlled release dosage forms developed in this
study present a slower release rate and higher extent of AUC.
Above all, it is proved to be developing matrix materials for
direct compression of controlled release dosage forms using
two common-used excipients of lactose and dicalcium phosphate.
|
|---|