Studies on rat Angiotrongylus cantonensis infection, experimental infection of Angiostrongylus cantonensis on canine and blood chemistry during infection

• Main Author: 柳源源
• Other Authors: 王俊秀
• Format: Others
• Language: zh-TW
• Published: 1993
• Online Access: http://ndltd.ncl.edu.tw/handle/38630559610585760962

碩士 === 國立中興大學 === 獸醫學研究所 === 81 === 　　In order to understand the condition of dogs after the infection of Angiostrongylus cantonensis, this experiment was performed. In this experiment dogs were divided into two groups , dogs of the first group were infected with 500 3rd stage larvae of Angiostrongylus cantonensis each. And the dogs of the second group were given ivermectin (0.05mg/kg, IM)every week for four weeks, rested for two weeks, then were infected with the same amount of 3rd stage larvae as the first group simultaneously with the first group. Blood was obtained from dogs of both group. and various tests were carried out to moniter the changes of blood CK, LDH, TP level and the antibody titer during the infection. 　　Tests results of the first gruop were as followed ; the LDH level began to increase during the 3rd week postinfection (pi) and reach the top during the 5th and 6th week pi, then started to decrease, There were no notable changed of blood CK level . Total protein started to increase right after the infection, reached the hightest level during the 4th, 5th and 6th week, and dropped to the level.before the infection during the 8th week pi. number of WBC also started to increase right after the infection adn were the hightest during the 3rd week pi. Antibody titer were raised during the 3rd week pi, reached the top during the 4-6th week, then gradually started to decrease. Dogs of the second group were still protected by ivermectin which were not completely metablized and were not infected. The test results of these dogs showed no significant differences as compared with the test results of the control group.