Summary: | 碩士 === 國立師範大學 === 化學學系 === 81 === Ligustici Rhizoma is a widely used Chinese herbal drug
which contains essential oils, organic acids, phenols,
alkloids and carbohydrates as its main components.
Pharmacological tests revealed that those essential oils
and organic acids had the functions of inhibiting cramped,
sedating, depress- ing the blood level and antifungaling. In
this study we used nicotinic acid, tetramethylpyrazine, ferulic
acid, butylphthalide, senkyunolide A , ligustilide and
butylidenephthalide as the reference standards to evaluate
the quality of commerical crude drugs by means of high-
performance liquid chromatography ( HPLC ). The scientific
significance of hebral processing were also investigated.
The analytical data showed that the contents of the
commerical crude drugs were as follows: nicotinic acid 0
- 0.05 mg/g, tetramethylpyrazine 0 -0.04 mg/g, ferulic acid
0.49 - 1.10 mg/g, butyl- phthalide 0.14 - 0.62 mg/g,
senkyunolide A 0.45 - 1.00 mg/g, ligustilide 4.00 - 8.55 mg/g,
butylidene- phthalide 1.33 - 2.19 mg/g. Basically the
contents of Ligustici Rhizoma were closely related to their
apperance. According to the results, it was found that the
contents of extractions were all increase after being
processed by different processing methods. Those methods
and their suitable processing times were as follows: fried
until became yellow in color - 40 minutes, fried with wine -
10 minutes, soaked with water - 3 hours, steamed with wine -
30 minutes . Among the above processing methods, that of fried
with wine could give excellent result. The organic acids
such as nicotinic acid , ferulic acid, p-hydroxybenzoic
acid, caffeic acid, protocatechuic acid, vanillic acid
etc. had also been subjected to capillary electrophoresis (
CE ) and a satisfactory separation was obtained too.
Nevertheless a further insight investigation was still
needed.
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