Regulation of p53 expression during cell cycle progression
碩士 === 國立成功大學 === 生物化學研究所 === 81 === Levine等人最早在研究SV40 large T antigen的致癌機轉時,發現large T antigen 在細胞中可和ㄧ個蛋白質結合,其分子量為53KDa,故命名為 p53.其基因後來被証實是ㄧ種腫瘤抑制基因.而p53在人類癌症中,扮演著 極重要的角色.有相當高比例的癌細胞中皆有p53突變的情形產生,若將原 型p53 (wild-type)導入癌細胞中,常可抑制癌...
Main Authors: | Can-Sen Lee, 李燦森 |
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Other Authors: | Ming-Derg Lai |
Format: | Others |
Language: | zh-TW |
Published: |
1993
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Online Access: | http://ndltd.ncl.edu.tw/handle/75118754487342707507 |
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