Relationship between C-myc proto-oncogene expression and DNA methylation in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

• Main Authors: Ming-Cheng Lin, 林明政
• Other Authors: Hung-Wen Liu
• Format: Others
• Language: zh-TW
• Published: 1993
• Online Access: http://ndltd.ncl.edu.tw/handle/86791823012568583410

碩士 === 高雄醫學院 === 醫學研究所 === 81 === Systemic Lupus Erythematosus (SLE) is a multisystem in fam- matory disorder characterized by the production of antibodies that react with many different self-antigens. However,little is known about their molecular pathogenesis. In this study, the peripheral blood mononuclear cells (PBMC) expression of c-myc proto-oncogene and 5-methylcytosine content C-myc proto- oncogene in samples of normal individuals and of patients who fulfilled the criteria of the American Rheumatism Association for the classification of SLE were investigated. The SLE patients ex- pressed an average of 1.6-fold increase c-myc mRNA levels. The methylation-pattern of the human c-myc proto- oncogene in patient with SLE does not differ from that of normal controls. These results indicated that methylation status of the gene are not responsible for the enhanced c-myc expression in PBMC of SLE patients.