| Summary: | 碩士 === 高雄醫學院 === 醫學研究所 === 81 === The prognosis in AML is still poor, which long-term disease-
free survival is only 20%. Since drug resistance remains the
major obstacle in this disease. We examined 28 samples from 24
patients with AML, the MDR1 RNA levels were determined by slot
blot analysis and compared with those of drug-resistive and
multidrug resistant cell lines. The MDR1 RNA expression was
negative in 28.6% and positive in 71.4% of the patients. Age,
WBC count, percentage oflast, LDH and induction chemotherapy
were not significantly difference between MDR1 RNA-negative and
positive patients. However, the complete remission rate was
lower for patients with MDR1 RNA positive than for those
negative group [26.3% (6/19) vs 80%(4/5)]. We had three cases,
their MDR1 RNA expression progressively elevated by disease
progression and number of chemotherapy. So we suggest that high
frequency of MDR1 gene expression in the AML, and the elevated
MDR1 RNAevels in the AML were associated with lower complete
remission rate, resistant disease, early death, and shorter
disease-free survival. So that the expression of MDR1 is a poor
prognostic factors for the AML treatment, and it may play an
important role in resistance to chemotherapy.
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