(1)Preparation of 3-Cyanopyridine and Benzonitrile by Ammoxidation (2)Synthesis of 2,4-Diamino-6-Substituted-Pteridine

(1)Preparation of 3-Cyanopyridine and Benzonitrile by Ammoxidation (2)Synthesis of 2,4-Diamino-6-Substituted-Pteridine

碩士 === 國立臺灣師範大學 === 化學學系 === 69 === 　　(1)3-Cyanopyridine is the intermediate for nicotinamide and nicotinic acid. Benzonitrile is the intermediate for homosulfamine. A procedure has now been established for the laboratory fluidized-bed ammoxidation of 3-picoloine and toluene to form 3-cyanopyridine...

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Main Authors: Sheu, Chuwn-Feng, 許春峰
Other Authors: Wang, Cheng-Hsia
Format: Others
Language:zh-TW
Online Access:http://ndltd.ncl.edu.tw/handle/14922522829322551978
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spelling ndltd-TW-069NTNU30650022015-10-13T12:34:16Z http://ndltd.ncl.edu.tw/handle/14922522829322551978 (1)Preparation of 3-Cyanopyridine and Benzonitrile by Ammoxidation (2)Synthesis of 2,4-Diamino-6-Substituted-Pteridine （一）以氨氧化法製備3-月青基口比啶，苯甲月青（二）2,4-二氨基-6-取代-嘧啶派口秦 Sheu, Chuwn-Feng 許春峰 碩士 國立臺灣師範大學 化學學系 69 　　(1)3-Cyanopyridine is the intermediate for nicotinamide and nicotinic acid. Benzonitrile is the intermediate for homosulfamine. A procedure has now been established for the laboratory fluidized-bed ammoxidation of 3-picoloine and toluene to form 3-cyanopyridine in 35.2% yield. benzonitrile in 47.5% yieldThe effects of reaction temperatures, mole ratios of reactants, and amounts of catalyst were studied. A convenient setup for laboratory ammoxidation was designed. 　　(2)Methotrexate (MTX) is an important anticancer drug widely used in cancer chemotherapy. 2,4-Diamino-6-substituted-pteridine (I) is the intermediate for MTX. In this research the intermediate I was synthesized from a pyrimidine derivative and also from a pyrazine derivative. Wang, Cheng-Hsia Chen, Chao-Tung 王澄霞 陳朝棟 學位論文 ; thesis 159 zh-TW
collection NDLTD
language zh-TW
format Others
sources NDLTD
description 碩士 === 國立臺灣師範大學 === 化學學系 === 69 === 　　(1)3-Cyanopyridine is the intermediate for nicotinamide and nicotinic acid. Benzonitrile is the intermediate for homosulfamine. A procedure has now been established for the laboratory fluidized-bed ammoxidation of 3-picoloine and toluene to form 3-cyanopyridine in 35.2% yield. benzonitrile in 47.5% yieldThe effects of reaction temperatures, mole ratios of reactants, and amounts of catalyst were studied. A convenient setup for laboratory ammoxidation was designed. 　　(2)Methotrexate (MTX) is an important anticancer drug widely used in cancer chemotherapy. 2,4-Diamino-6-substituted-pteridine (I) is the intermediate for MTX. In this research the intermediate I was synthesized from a pyrimidine derivative and also from a pyrazine derivative.
author2 Wang, Cheng-Hsia
author_facet Wang, Cheng-Hsia
Sheu, Chuwn-Feng
許春峰
author Sheu, Chuwn-Feng
許春峰
spellingShingle Sheu, Chuwn-Feng
許春峰
(1)Preparation of 3-Cyanopyridine and Benzonitrile by Ammoxidation (2)Synthesis of 2,4-Diamino-6-Substituted-Pteridine
author_sort Sheu, Chuwn-Feng
title (1)Preparation of 3-Cyanopyridine and Benzonitrile by Ammoxidation (2)Synthesis of 2,4-Diamino-6-Substituted-Pteridine
title_short (1)Preparation of 3-Cyanopyridine and Benzonitrile by Ammoxidation (2)Synthesis of 2,4-Diamino-6-Substituted-Pteridine
title_full (1)Preparation of 3-Cyanopyridine and Benzonitrile by Ammoxidation (2)Synthesis of 2,4-Diamino-6-Substituted-Pteridine
title_fullStr (1)Preparation of 3-Cyanopyridine and Benzonitrile by Ammoxidation (2)Synthesis of 2,4-Diamino-6-Substituted-Pteridine
title_full_unstemmed (1)Preparation of 3-Cyanopyridine and Benzonitrile by Ammoxidation (2)Synthesis of 2,4-Diamino-6-Substituted-Pteridine
title_sort (1)preparation of 3-cyanopyridine and benzonitrile by ammoxidation (2)synthesis of 2,4-diamino-6-substituted-pteridine
url http://ndltd.ncl.edu.tw/handle/14922522829322551978
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