An Exploration into the Molecular Recognition of Signal Transducer and Activator of Transcription 3 Protein Using Rationally Designed Small Molecule Binders

An Exploration into the Molecular Recognition of Signal Transducer and Activator of Transcription 3 Protein Using Rationally Designed Small Molecule Binders

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Signal transducer and activator of transcription 3 (STAT3) is a cancer-driving proto-oncoprotein that represents a novel target for the development of chemotherapeutics. In this study, the functional requirements to furnish a potent STAT3 inhibitor was investigated. First, a series of peptidomimetic...

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Bibliographic Details
Main Author: Shahani, Vijay Mohan
Other Authors: Gunning, Patrick T.
Language:en_ca
Published: 2013
Subjects:
Inhibitor design
STAT3
Protein-protein interaction
Molecular recognition
Molecular modelling
Pharmacophore model
Antitumour cell effects
SH2 domain
0491
Online Access:http://hdl.handle.net/1807/43719

Internet

http://hdl.handle.net/1807/43719

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