Role of Patched-1 Intracellular Domains in Canonical and Non-Canonical Hedgehog Signalling Events
Patched-1 (Ptch1) is the primary receptor for Hedgehog (Hh) ligands and mediates both canonical and non-canonical Hh signalling. Previously, our lab identified that mice possessing a Ptch1 C-terminal truncation display blocked mammary gland development at puberty that is overcome by overexpression o...
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| Language: | en_ca |
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2013
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| Online Access: | http://hdl.handle.net/1807/42877 |