Microfluidic Modeling of Cell Flow & Self-assembly of Gold Nanorods with Different Lengths

• Main Author: Chung, Siyon
• Other Authors: Kumacheva, Eugenia
• Language: en_ca
• Published: 2012
• Subjects: Microfluidics; Self-assembly; Nanochemistry; Step-growth polymerization; Modeling cell flow; 0495
• Online Access: http://hdl.handle.net/1807/35514

The thesis is divided into two parts: (1) microfluidic modeling of blood cell flow in constricted microvasculature and (2) the kinetic study of self-assembly of Au nanorods with different lengths. The passive mechanism of the flow of neutrophils was studied by using poly(dimethyl siloxane) microchannels with circular cross-sections as model blood vessels and agarose microgels as model cells. Their velocity and pressure profiles at various locations inside the microchannel with constrictions were studied as functions of (a) the initial velocity of the microgels, (b) the degree at which the channel-at-large tapered into the constriction, and (c) the size of microgels. Previously, our group proposed that the kinetics of self-assembly of Au nanorods resembles that of the reaction-controlled step-growth polymerization. To investigate factors that affect the reactivity of functional groups, self-assembly experiments were performed for nanorods with different lengths and their kinetics was analyzed.