The Development and Application of Tools to Study the Multiscale Biomechanics of the Aortic Valve

The Development and Application of Tools to Study the Multiscale Biomechanics of the Aortic Valve

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Calcific aortic valve disease (CAVD) is one of the most common causes of cardiovascular disease in North America. Mechanical factors have been closely linked to the pathogenesis of CAVD and may contribute to the disease by actively regulating the mechanobiology of valve interstitial cells (VICs). Me...

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Bibliographic Details
Main Author: Zhao, Ruogang
Other Authors: Simmons, Craig Alexander
Language:en_ca
Published: 2012
Subjects:
biomechanics
aortic valve
valve interstitial cell
viscoelastic material property
micropipette aspiration
valve tissue mechanics
fibrosa and ventricularis
finite element model
digital image correlation
texture correlation
intracellular strain transfer
apoptosis and anoikis
hyperelastic material
RGD peptide
tension-release
loss of adhesion
valve calcification
multilayer tissue
gelatin gel
inverse finite element method
cell stretching
exponential strain energy function
0541
Online Access:http://hdl.handle.net/1807/33866
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