Examining a Role for Planar Cell Polarity Signaling in Endothelial Cell Alignment and Organization

Examining a Role for Planar Cell Polarity Signaling in Endothelial Cell Alignment and Organization

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Endothelial cells (ECs) respond to flow but the exact mechanism producing alignment is not completely understood. We characterized EC alignment in microfluidic channels, 4 mm wide by 350 um high, to generate shear of 20 dynes / cm2 across the cell surface. In microchannels, ECs aligned perpendicular...

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Bibliographic Details
Main Author: Brunetti, Jonathan A.
Other Authors: McGuigan, Alison P.
Language:en_ca
Published: 2012
Subjects:
planar cell polarity (PCP)
endothelial cells
shear flow
microfluidic
0541
Online Access:http://hdl.handle.net/1807/33497

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