V-ATPase a3-d2 and a3-B2 Subunit Interaction in Osteoclasts are Viable Targets for Anti-resorptive Therapeutics

V-ATPase a3-d2 and a3-B2 Subunit Interaction in Osteoclasts are Viable Targets for Anti-resorptive Therapeutics

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For bone resorption, vacuolar-type H+-ATPases (V-ATPases) on the plasma membranes of osteoclasts acidifies the extracellular millieu adjacent to the bone surface. The V-ATPase a3 and d2 subunits are enriched in osteoclasts. B2 subunit is also expressed on the osteoclast plasma membrane. Disruption...

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Bibliographic Details
Main Author: Crasto, Gazelle Jean
Other Authors: Manolson, Morris Frank
Language:en_ca
Published: 2012
Subjects:
Bone
V-ATPase
osteoclast
drug development
Luteolin
0567
0487
Online Access:http://hdl.handle.net/1807/32236

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