Characterizing the Role of Stromal Cell Derived Factor 2 Like-1 (SDF2L1) in Pancreatic β-Cells
Type 2 diabetes is characterized by insulin resistance and pancreatic β-cell failure. Insulin resistance leads to increased insulin demand, which can lead to increased proinsulin misfolding in the endoplasmic reticulum (ER). The accumulation of the misfolded proteins in the ER can cause ER stress,...
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| Language: | en_ca |
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2011
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| Online Access: | http://hdl.handle.net/1807/31464 |