A Global Kinase and Phosphatase Interaction Network in the Budding Yeast Reveals Novel Effectors of the Target of Rapamycin (TOR) Pathway

A Global Kinase and Phosphatase Interaction Network in the Budding Yeast Reveals Novel Effectors of the Target of Rapamycin (TOR) Pathway

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In the budding yeast Saccharomyces cerevisiae, the evolutionarily conserved Target of Rapamycin (TOR) signaling network regulates cell growth in accordance with nutrient and stress conditions. In this work, I present evidence that the TOR complex 1 (TORC1)-interacting proteins Nnk1, Fmp48, Mks1, and...

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Bibliographic Details
Main Author: Sharom, Jeffrey Roslan
Other Authors: Tyers, Michael D.
Language:en_ca
Published: 2011
Subjects:
Target of Rapamycin
budding yeast
Saccharomyces cerevisiae
yeast
kinase
phosphatase
protein-protein interactions
TOR
nutrients
growth
rapamycin
signaling
network
metabolism
nitrogen catabolite repression
retrograde response
glutamate dehydrogenase
glutamine
glutamate
alpha-ketoglutarate
cell size
aging
lifespan
mitochondria
uncoupled respiration
petite
reactive oxygen species
free radical theory of aging
apoptosis
cancer
glutaminolysis
TORC1
Nnk1
Fmp48
Mks1
Sch9
Gdh2
Ure2
ribosomal protein S6 kinase
S6K
cell biology
molecular biology
0307
0379
0369
0410
0306
Online Access:http://hdl.handle.net/1807/29864

Internet

http://hdl.handle.net/1807/29864

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