Use of Lanthanide Ions for Encoding One-bead-one-compound Combinatorial Libraries

Use of Lanthanide Ions for Encoding One-bead-one-compound Combinatorial Libraries

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The advantage of one-bead-one-compound combinatorial libraries is that hundreds of thousands to millions of compounds can be rapidly synthesized and screened simultaneously. The beads supporting the compounds of interest are then isolated and analyzed to decipher the structure of the desired compoun...

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Main Author: Ng, Grace Pik Ling
Other Authors: Nitz, Mark
Language:en_ca
Published: 2009
Subjects:
Lanthanide
combinatorial chemistry
ICP-MS
TentaGel
0486
0487
Online Access:http://hdl.handle.net/1807/26442
id ndltd-TORONTO-oai-tspace.library.utoronto.ca-1807-26442
record_format oai_dc
spelling ndltd-TORONTO-oai-tspace.library.utoronto.ca-1807-264422014-01-23T04:01:48ZUse of Lanthanide Ions for Encoding One-bead-one-compound Combinatorial LibrariesNg, Grace Pik LingLanthanidecombinatorial chemistryICP-MSTentaGel04860487The advantage of one-bead-one-compound combinatorial libraries is that hundreds of thousands to millions of compounds can be rapidly synthesized and screened simultaneously. The beads supporting the compounds of interest are then isolated and analyzed to decipher the structure of the desired compound. Many methods are currently used to allow deconvolution of the compound on the individual beads. Herein is described a novel method to encode TentaGel beads using absorption of different ratios of lanthanide ions. The encoding process is completed in parallel with the synthesis of the library of compounds. Once the desired beads are identified, the lanthanide ions can be released from the bead and analyzed using Inductively Coupled Plasma-Mass Spectrometry (ICP-MS).Nitz, Mark2009-062011-03-02T13:57:34ZWITHHELD_ONE_YEAR2011-03-02T13:57:34Z2011-03-02T13:57:34ZThesishttp://hdl.handle.net/1807/26442en_ca
collection NDLTD
language en_ca
sources NDLTD
topic Lanthanide
combinatorial chemistry
ICP-MS
TentaGel
0486
0487
spellingShingle Lanthanide
combinatorial chemistry
ICP-MS
TentaGel
0486
0487
Ng, Grace Pik Ling
Use of Lanthanide Ions for Encoding One-bead-one-compound Combinatorial Libraries
description The advantage of one-bead-one-compound combinatorial libraries is that hundreds of thousands to millions of compounds can be rapidly synthesized and screened simultaneously. The beads supporting the compounds of interest are then isolated and analyzed to decipher the structure of the desired compound. Many methods are currently used to allow deconvolution of the compound on the individual beads. Herein is described a novel method to encode TentaGel beads using absorption of different ratios of lanthanide ions. The encoding process is completed in parallel with the synthesis of the library of compounds. Once the desired beads are identified, the lanthanide ions can be released from the bead and analyzed using Inductively Coupled Plasma-Mass Spectrometry (ICP-MS).
author2 Nitz, Mark
author_facet Nitz, Mark
Ng, Grace Pik Ling
author Ng, Grace Pik Ling
author_sort Ng, Grace Pik Ling
title Use of Lanthanide Ions for Encoding One-bead-one-compound Combinatorial Libraries
title_short Use of Lanthanide Ions for Encoding One-bead-one-compound Combinatorial Libraries
title_full Use of Lanthanide Ions for Encoding One-bead-one-compound Combinatorial Libraries
title_fullStr Use of Lanthanide Ions for Encoding One-bead-one-compound Combinatorial Libraries
title_full_unstemmed Use of Lanthanide Ions for Encoding One-bead-one-compound Combinatorial Libraries
title_sort use of lanthanide ions for encoding one-bead-one-compound combinatorial libraries
publishDate 2009
url http://hdl.handle.net/1807/26442
work_keys_str_mv AT nggracepikling useoflanthanideionsforencodingonebeadonecompoundcombinatoriallibraries
_version_ 1716627321006325760

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