High Frequency Ultrasound Backscatter Analysis for the Detection of Early Tumour Response to Radiotherapy and a Novel Anti-vascular Treatment
There is a need for cancer imaging to provide “real-time” information about the cellular responses of tumours in contrast to standard evaluations of tumour size. Quantitative ultrasound techniques have recently been demonstrated to be a potential method of assessing tumour response at the cellular l...
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| Language: | en_ca |
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2010
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| Online Access: | http://hdl.handle.net/1807/25778 |
| Summary: | There is a need for cancer imaging to provide “real-time” information about the cellular responses of tumours in contrast to standard evaluations of tumour size. Quantitative ultrasound techniques have recently been demonstrated to be a potential method of assessing tumour response at the cellular level through the analysis of radiofrequency backscatter data.
In this thesis, prostate cancer xenografts were evaluated in vivo using high-frequency ultrasound analysis techniques to assess tumour response. The anti-cancer treatments consisted of radiotherapy and also a novel anti-vascular therapy utilizing encapsulated microbubble agents in the presence of ultrasound. Quantitative ultrasound results demonstrated a statistically significant change in backscatter parameters in tumours treated with high doses of radiotherapy or a high concentration of microbubbles during treatments. Histopathological assessment demonstrated that tumour cell death due to apoptosis and necrosis correlated with increases in ultrasound parameters. |
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