Enhancing Interfacial Bonding of a Biodegradable Calcium Polyphosphate/Polyvinyl-urethane Carbonate Interpenetrating Phase Composite for Load Bearing Fracture Fixation Applications

• Main Author: Guo, Yi
• Other Authors: Pilliar, Robert M.
• Language: en_ca
• Published: 2010
• Subjects: Orthopaedic; Interpenetrating Phase Composite; Calcium Polyphosphate; Polyvinylurethane; Fracture Fixation; Load Bearing Bones; Biodegradable Composite; Mechanical Testing; silanizing agents; silane; 0541; 0794
• Online Access: http://hdl.handle.net/1807/24251

This thesis describe methods to improve the interfacial stability of an interpenetrating phase composite (IPC) polyvinylurethanecarbonate), and to increase the hydrophobicity of the polymer phase. The current IPCs introduce covalent bonding between the phases via silanizing agents to enhance the interfacial stability. Incorporation of the silanizing agents was also intended to reduce the IPC’s sensitivity to interfacial hydration, thereby enhancing the IPC’s resistance to degradation during aging. Lysine diisocyanate was used to increase the hydrophobic character in the polyvinylurethanecarbonate resin. The polymer resins were infiltrated into porous CPP blocks with 25 volume% interconnected porosity and polymerized to produce the IPCs. After mechanical testing following a aging study it was found that the silanizing agents contributed to stability of the mechanical properties under aqueous conditions. It was concluded that the mechanical properties and stability were comparable to available biodegradable composites, as well as being biocompatible to a preosteoblast model cell line.