Single Channel Conductance of the CaV2.2 Calcium Channel

Single Channel Conductance of the CaV2.2 Calcium Channel

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Calcium ions (Ca2+) are admitted into presynaptic nerve terminals through voltage gated calcium channels and diffuse to bind and activate the secretory vesicle discharge mechanism. Current research favors a highly ‘modal’ organization where the release sites are activated by one or a few closely...

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Bibliographic Details
Main Author: Weber, Alexander M.
Other Authors: Stanley, Elise F.
Language:en_ca
Published: 2009
Subjects:
Single-channel
Calcium
Conductance
Physiological
CaV2.2
N-type
0719
0317
Online Access:http://hdl.handle.net/1807/18991
id ndltd-TORONTO-oai-tspace.library.utoronto.ca-1807-18991
record_format oai_dc
spelling ndltd-TORONTO-oai-tspace.library.utoronto.ca-1807-189912013-11-08T04:03:53ZSingle Channel Conductance of the CaV2.2 Calcium ChannelWeber, Alexander M.Single-channelCalciumConductancePhysiologicalCaV2.2N-type07190317Calcium ions (Ca2+) are admitted into presynaptic nerve terminals through voltage gated calcium channels and diffuse to bind and activate the secretory vesicle discharge mechanism. Current research favors a highly ‘modal’ organization where the release sites are activated by one or a few closely apposed channels (Stanley, 1997). To fully understand the nanophysiology of transmitter release site activation, it is necessary to determine the rate of Ca2+ flux through individual channels at normal physiological external concentrations. OBJECTIVE: To explore the relationship between CaV2.2 channel conductance and external Ca2+ across the physiological range. CONCLUSION: The conductance of the CaV2.2 channel was determined across the range of 1-100 mM [Ca2+]EXT . With 2 mM [Ca2+]EXT, the conductance was determined to be 2.76 ± 0.24 pS.Stanley, Elise F.2009-112010-02-17T17:46:55ZNO_RESTRICTION2010-02-17T17:46:55Z2010-02-17T17:46:55ZThesishttp://hdl.handle.net/1807/18991en_ca
collection NDLTD
language en_ca
sources NDLTD
topic Single-channel
Calcium
Conductance
Physiological
CaV2.2
N-type
0719
0317
spellingShingle Single-channel
Calcium
Conductance
Physiological
CaV2.2
N-type
0719
0317
Weber, Alexander M.
Single Channel Conductance of the CaV2.2 Calcium Channel
description Calcium ions (Ca2+) are admitted into presynaptic nerve terminals through voltage gated calcium channels and diffuse to bind and activate the secretory vesicle discharge mechanism. Current research favors a highly ‘modal’ organization where the release sites are activated by one or a few closely apposed channels (Stanley, 1997). To fully understand the nanophysiology of transmitter release site activation, it is necessary to determine the rate of Ca2+ flux through individual channels at normal physiological external concentrations. OBJECTIVE: To explore the relationship between CaV2.2 channel conductance and external Ca2+ across the physiological range. CONCLUSION: The conductance of the CaV2.2 channel was determined across the range of 1-100 mM [Ca2+]EXT . With 2 mM [Ca2+]EXT, the conductance was determined to be 2.76 ± 0.24 pS.
author2 Stanley, Elise F.
author_facet Stanley, Elise F.
Weber, Alexander M.
author Weber, Alexander M.
author_sort Weber, Alexander M.
title Single Channel Conductance of the CaV2.2 Calcium Channel
title_short Single Channel Conductance of the CaV2.2 Calcium Channel
title_full Single Channel Conductance of the CaV2.2 Calcium Channel
title_fullStr Single Channel Conductance of the CaV2.2 Calcium Channel
title_full_unstemmed Single Channel Conductance of the CaV2.2 Calcium Channel
title_sort single channel conductance of the cav2.2 calcium channel
publishDate 2009
url http://hdl.handle.net/1807/18991
work_keys_str_mv AT weberalexanderm singlechannelconductanceofthecav22calciumchannel
_version_ 1716613767123435520

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