Examination of NMDA receptor subunit prevalence and distribution in crude synaptic membranes purified from a mouse model of Rett syndrome.

Examination of NMDA receptor subunit prevalence and distribution in crude synaptic membranes purified from a mouse model of Rett syndrome.

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In this study we tested whether the prevalence or synaptic distribution of NMDA receptor subunits would be altered in the brain of the MeCP2-null mouse model of Rett syndrome. Detergent resistant membranes (DRMs) and post-synaptic densities (PSDs) were isolated from the synaptic membranes treated wi...

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Bibliographic Details
Main Author: Maliszewska-Cyna, Ewelina
Other Authors: Eubanks, James
Language:en_ca
Published: 2009
Subjects:
Rett syndrome
MeCP2
epigenetics
neurodevelopment
synaptic maturation
glutamate
NMDA receptor complex
NR2A
biochemical purification of crude synaptic membranes
lipid rafts
postsynaptic density
discontinuous sucrose gradient
0719
0317
Online Access:http://hdl.handle.net/1807/18983

Internet

http://hdl.handle.net/1807/18983

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