HMG-CoA Reductase Inhibition Reduces T-cell Activation, TNFα Production, and MMP-9 Gene Expression in a Superantigen-mediated Mouse Model of Kawasaki Disease

HMG-CoA Reductase Inhibition Reduces T-cell Activation, TNFα Production, and MMP-9 Gene Expression in a Superantigen-mediated Mouse Model of Kawasaki Disease

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Kawasaki disease (KD) is a multisystem vasculitis leading to coronary artery aneurysm formation. In a superantigen-mediated murine model of KD, the development of coronary arteritis is mediated by T-cells through the production of TNFα. TNFα localizes to the coronary arteries, where it induces the e...

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Bibliographic Details
Main Author: Blankier, Shawn Adam
Other Authors: Ito, Shinya
Language:en_ca
Published: 2009
Subjects:
Kawasaki Disease
Statins
0982
Online Access:http://hdl.handle.net/1807/17495

Internet

http://hdl.handle.net/1807/17495

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