Nicotine addiction phenotypes in a BAC transgenic mouse model overexpressing the CHRNA5/A3/B4 genomic cluster

Nicotine addiction phenotypes in a BAC transgenic mouse model overexpressing the CHRNA5/A3/B4 genomic cluster

The CHRNA5/A3/B4 genomic cluster encodes for the alpha5, alpha3 and beta4 subunits of the nicotinic acetylcholine receptors (nAChRs). Human genetic studies have revealed a significant association of variants in this genomic region with nicotine dependence. However, the mechanisms through which overe...

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Bibliographic Details
Main Author: Molas Casacuberta, Susanna, 1985-
Other Authors: Dierssen, Mara
Format: Doctoral Thesis
Language:English
Published: Universitat Pompeu Fabra 2012
Subjects:
Nicotine addiction
Cluster CHRNA5/A3/B4
nAChRs
Cognition
Hippocampus
Neural plasticity
Medial habenula
Adicció a la nicotina
Cognició
Hipocamp
Plasticitat neuronal
Habenula medial
616.89
Online Access:http://hdl.handle.net/10803/104155

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